FebriDx measures two host-response proteins — CRP and MxA — simultaneously to differentiate bacterial from non-bacterial acute respiratory infections with clinical-grade accuracy.
Pathogens leave the immune system a measurable fingerprint. FebriDx reads two of them at once — a dual signature no single-marker assay can match.
C-Reactive Protein
An acute-phase protein produced by the liver in response to inflammatory cytokines like IL-6. Rises in both bacterial and viral infection — sensitive, but not specific enough on its own.
Myxovirus Resistance Protein A
An innate biomarker induced exclusively by interferon during viral infection. Not elevated by bacteria — giving FebriDx the specificity a CRP-only test cannot achieve.
Neither MxA nor CRP alone is sensitive or specific enough to differentiate bacterial infection from non-bacterial etiology. However, when both host response biomarkers are measured together in the FebriDx test, bacterial infection can be reliably differentiated from non-bacterial etiologies.
A prospective, multi-center, double-blinded U.S. trial conducted between October 2019 and April 2021 and published in JAMA Network Open.
When FebriDx reads negative for bacterial infection, it is right 98.7% of the time — giving clinicians the confidence to safely withhold antibiotics.
Shapiro NI, Filbin MR, Hou PC, et al. JAMA Network Open. 2022;5(10):e2234588.
Read the full studyAcute respiratory infections are the most common reason for physician office visits and antibiotic prescriptions worldwide. The significant overlap in symptoms makes it challenging to differentiate bacterial from non-bacterial infections.
The vast majority of ARIs are caused by non-bacterial etiology, yet 30-80% receive antibiotics. This overprescription is a leading contributor to the global antimicrobial resistance crisis, which currently causes over 1.27 million deaths annually.
FebriDx supports antimicrobial stewardship by giving clinicians an objective, rapid tool to determine whether antibiotics are truly needed — reducing unnecessary prescriptions while ensuring bacterial infections are not overlooked.
